Jane Grimwood

Jane GrimwoodJane received her B.Sc. and Ph.D. in Microbiology from the University of Leeds in the United Kingdom, followed by postdoctoral training at the University of Oxford, Dartmouth College and the University of San Francisco. Since 2000, she was a Senior Scientist at the Stanford Human Genome Center where she and her group were responsible for finishing and performing quality analysis on the 320 million base pairs of human chromosomes 5, 16 and 19, comprising more than 10% of the human genome. After the completion of the Human Genome Project, Jane continues to lead a group that now focuses on sequencing, finishing and genome improvement of a wide variety of eukaryotic genomes, including plants, fungi, and vertebrates. She joined HudsonAlpha in 2008.

Research interests

  • Genome improvement and finishing of eukaryotic organisms
  • Cloning systems
  • Host/pathogen interactions at the cellular and genomic levels
  • Comparative sequence analysis

Selected publications

Schmutz J, Cannon SB, Schlueter J, Ma J, Mitros T ... Grimwood J, Rokhsar D, Stacey G, Shoemaker RC, Jackson SA. (2010). Genome sequence of the palaeopolyploid soybean. Nature. 463 (7278): 178-183. (PDF)

Palenik B, Grimwood J, Aerts A ... Schmutz J, Rokhsar D, Van de Peer Y, Moreau H, Grigoriev IV. (2007). The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation. PNAS. 104: 7705-7710. (PDF)

Jeffries TW, Grigoriev IV, Grimwood J, Laplaza JM, Aerts A, Salamov A, Schmutz J, Lindquist E, Dehal P, Shapiro H, Jin YS, Passoth V, Richardson PM. (2007). Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis. Nature Biotechnology. 25: 319-326. (PDF)

Colosimo PF, Hosemann KE, Balabhadra S, Villareal G, Dickson M, Grimwood J, Schmutz J, Myers RM, Schluter D, Kingsley DM. (2005). Widespread parallel evolution of stickleback armor plates determined by ancestral genetic variation in Ectodysplasin. Science. 307: 1928- 1933. (PDF)

Schmutz J, Wheeler J, Grimwood J, Dickson M ... Salazar A, Tsai M, Myers RM. (2004). Quality assessment of the human genome sequence. Nature. 429(6690): 365-368. (PDF)

Noonan JP, Grimwood J, Danke J, Schmutz J, Dickson M, Amemiya CT, Myers RM. (2004). Coelacanth genome sequence reveals the evolutionary history of vertebrate genes. Genome Research. 12: 2397-2405. (PDF)

Grimwood J, Gordon LA, Terry A, Olsen A, Schmutz J ... Branscomb E, Rokhsar DS, Myers RM, Rubin EM, Lucas SM. (2004). The DNA sequence and biology of human chromosome 19. Nature. 428: 529-535. (PDF)

Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan J, Zhang M, Myers RM, Maniatis T. (2001). Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research. 11: 389-404. (PDF)

Kalman S, Mitchell W, Marathe R, Lammel C, Fan J, Hyman RW, Olinger L, Grimwood J, Davis RW, Stephens RS. (1999). Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nature Genetics. 21: 385-389. (PDF)

Grimwood J, Mineo JR, Kasper LH. (1996). Attachment of Toxoplasma gondii to host cells is cell-cycle dependent. Infection and Immnity. 64: 4099-4104. (PDF)